Organ-specific autoimmunity

Cover of: Organ-specific autoimmunity |

Published by M. Dekker in New York .

Written in English

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  • Autoimmune diseases.,
  • Autoimmunity.,
  • Autoimmune Diseases -- immunology.,
  • Autoimmunity.

Edition Notes

Includes bibliographical references and index.

Book details

Statementedited by Pierluigi E. Bigazzi, Georg Wick, Konrad Wicher.
SeriesImmunology series ;, v. 52
ContributionsBigazzi, Pierluigi E., Wick, G., Wicher, Konrad.
LC ClassificationsRC600 .O74 1990
The Physical Object
Paginationxiii, 388 p. :
Number of Pages388
ID Numbers
Open LibraryOL1852276M
ISBN 100824783360
LC Control Number90003886

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Autoimmune diseases are common diseases in which dysfunctional immune activation results in pathologic immune responses that target either cellular or organ-specific self-antigens. There is a genetic tendency towards autoreactivity in affected individuals and both innate and adaptive immune activation may contribute to disease.

Organ-Specific Autoimmunity (Immunology Series): Medicine & Health Science Books @ Organ-Specific Autoimmune Disease. Organ-specific autoimmune diseases are a loosely defined collection of disorders characterized by broadly shared aspects of presumed pathogenesis (i.e., the interplay of genetic predispositions, environmental insults, and destructive immune responses) and a relative restriction of pathology to defined cell types, tissues, and/or organs.

Additional Physical Format: Online version: Organ-specific autoimmunity. New York: M. Dekker, © (OCoLC) Document Type: Book: All Authors / Contributors.

In this review, we have first considered chemical-induced, organ-specific autoimmunity and then chemical-induced systemic autoimmunity.

Numerous drugs are known to induce immune-mediated hepatitis. Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and This is the first book to address all aspects of the biology of autoantibodies in a single volume, including a discussion of immunology, experimental models, clinical aspects, and the use of autoantibodies as probes in molecular and cellular biology.

His major research. Additional Physical Format: Online version: Endocrine and organ specific autoimmunity. Austin, Tex., U.S.A.: RlG.

Landes Co., © (OCoLC) The Rose–Witebski criteria for organ-specific autoimmunity are entirely fulfilled in infection-negative biopsy-proven myocarditis/in inflammatory cardiomyopathy (e.g., myocarditis with. Since publication of the 4th Edition of The Autoimmune Diseases inthe understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened.

This fully revised 5th Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies Book Edition: 5. For decades, research in autoimmunity has focused primarily on immune contributions to disease.

Yet recent studies report elevated levels of reactive oxygen species and abnormal activation of the unfolded protein response in cells targeted by autoimmunity, implicating cellular stress originating from the target tissue as a contributing factor.

A better understanding of this Cited by: Autoimmunity is the system of immune Organ-specific autoimmunity book of an organism against its own healthy cells and tissues.

Any disease that results from such an aberrant immune response is termed an "autoimmune disease".Prominent examples include celiac disease, post-infectious IBS, diabetes mellitus type 1, Henloch Scholein Pupura (HSP) sarcoidosis, systemic lupus erythematosus Specialty: Immunology. This textbook, edited by Robert Lahita MD of Lupus textbook fame is a different approach to autoimmune diseases.

The first part of the book offers an overview of the main aspects of immune response in basic science, while part 2 deals with the clinical aspects of that he dedicates 12 chapters to approaching the autoimmune diseases by /5(4).

Autoimmunity is defined as an immune response against a self-antigen. This Organ-specific autoimmunity book immune response can lead to tissue damage and to the development of autoimmune disease.

From organ-specific autoimmune diseases, such as myasthenia gravis, to non-organ-specific, such as systemic lupus erythematosus, autoimmune diseases represent a heterogeneous group of Author: Katerina Chatzidionysiou.

The results show that at least two steps are required for autoimmunity: (1) activation of antigen‐specific T cells, and (2) conditioning of the target organ.

It will be important to determine the factors leading to conditioning but it is likely that adhesion molecules are by: 9. Cite this entry as: () Organ-Specific Autoimmunity.

In: Vohr HW. (eds) Encyclopedia of Immunotoxicology. Springer, Berlin, Heidelberg. Organ-specific autoimmunity book. Definition. Autoimmunity can be defined as breakdown of mechanisms responsible for self tolerance and induction of an immune response against components of the self.

Such an immune response may not always be harmful (e.g., anti-idiotype antibodies). These diseases may fall in an organ-specific category in which the immune. than one organ-specific or and systemic autoimmune disease in the same time?.

• Explain the involvement of genetic factors in autoimmunity. • Determine if the formed immune complexes either associated with organ-specific or systemic autoimmunity. • Determine if there are any autoreactive T and B lymphocytes normally present in normal Size: 1MB.

Organ-Specific Autoimmunity by Pierluigi E. Bigazzi,available at Book Depository with free delivery worldwide. Autoimmunity, on the other hand, refers merely to the presence of antibodies or T lymphocytes that react with self-antigens and does not necessarily imply that the self-reactivity has pathogenic consequences.

Autoimmunity is present in all individuals; however, autoimmune disease occurs only in those individuals in whom the breakdown of one or. Autoimmune polyglandular syndromes (APS) are conditions characterized by the association of two or more organ-specific disorders.

Type 2 APS is defined by the occurrence of Addison's disease with thyroid autoimmune disease and/or Type 1 diabetes by: MODULE Autoimmunity and Autoimmune Diseases Microbiology Notes glands) or it may involve particular cells/tissues all over the body when it is called non-organ specific or disseminated disease (e.g.

Rheumatoid arthritis). OBJECTIVES After reading this lesson you will be able to: zdefine autoimmunity zdescribe the history of autoimmunityFile Size: 1MB.

There is also evidence for down-regulation of the T helper 2 cell-dependent CDw60 molecules in the vitiliginous epidermis. This observation correlates with infiltrating T cells exhibiting a T helper 1 cell-type cytokine production pattern consistent with cell-mediated organ-specific by: 1.

Learning Objectives. Explain why autoimmune disorders develop; Provide a few examples of organ-specific and systemic autoimmune diseases; Inartist Walt Kelly developed a poster promoting Earth Day, featuring a character from Pogo, his daily newspaper comic the poster, Pogo looks out across a litter-strewn forest and says wryly, “We have met the enemy.

Find many great new & used options and get the best deals for Annals of the New York Academy of Sciences: Autoimmune Diseases and Treatment: Organ-Specific and Systemic Disorders Vol.

by Yehuda Shoenfeld (, Paperback) at the best online prices at eBay. Free shipping for many products. To safeguard against this, there is a type of regulatory T-cell (T-regs) that recognizes self-antigens and suppresses auto-reactive cells that are improperly selected. A failure in T-reg-mediated tolerance can result in autoimmunity without a defect in selection due to the molecular mimicry of foreign microbes.

The Molecular Pathology of Autoimmune Diseases is a concise and centralized resource for information on the topic, with a special focus on the molecular and genetic basis of these disorders. Dozens of international experts devote themselves to illuminating the reader in this volume, with discussions on the basic aspects of autoimmune processes.

To understand how B cells are normally prevented from reacting to self-tissue, what goes wrong in autoimmunity, and how B cells contribute to it is the aim of this book. This volume includes more than a dozen in-depth reviews by researchers specializing in various aspects of basic B cell biology that have relevance to autoimmune diseases.

Type 1 Diabetes: Molecular, Cellular and Clinical Immunology communicates both the background and the most recent understanding of this disorder, which will almost certainly be central to elucidating the etiology of autoimmunity, and in particular of organ specific autoimmunity.

The book covers immunogenetics, immunopathogenesis, epidemiology. Other autoimmune disorders are non-organ specific and instead the activity is spread throughout the body. Examples include rheumatoid arthritis and lupus.

Of the inflammatory bowel diseases (IBD), ulcerative colitis is an organ specific disorder (colon) while Crohn’s disease is a bit of a cross between the two, because it can affect any part.

Normally, the presence of self-reactive (autoimmune) cells does not always lead to autoimmune diseases because their numbers are small and are kept in check by peripheral tolerance mechanisms.

In this sense, autoimmunity should be distinguished from autoimmune diseases. The biologic effectors that amplify many immunologic reactions that lead to important biologic Cited by: 1. Graves disease is a organ specific autoimmunity ego antibodies against the TSH is responsible for the high production of thyroid endocrine.

Hyperthyroidism is the chief cause of Gravess ‘ disease. Some authors divide the APS-II syndrome based upon the specific disease components reserving APS-II for Addison’s disease plus autoimmune thyroid disease or type 1 diabetes (e.g. APS-III for thyroid autoimmunity plus other autoimmune (not Addison’s or hypoparathyroidism); APS-IV for two or more other organ specific autoimmune diseases).

Exact causes for autoimmune diseases remain unclear and no cures are available. Breakdown of immunotolerance could set the stage for unfettered immune responses that target self-antigens. Impaired regulatory immune mechanisms could have permissive roles in autoreactivity. Abnormal regulatory immune cell function, therefore, might be a major determinant of the pathogenesis Cited by: 1.

Autoimmune diseases can be classified into clusters that are typically either organ-specific or systemic Aichele P, Bachmann M F, Hengartner H, Zinkernagel R M. Immunopathology or organ-specific autoimmunity as a consequence of virus infection.

Type 1 Diabetes. Juvenile diabetes, or type 1 diabetes mellitus, is usually diagnosed in children and young adults.

It is a T-cell-dependent autoimmune disease characterized by the selective destruction of the β cells of the islets of Langerhans in the pancreas by CD4 T H 1-mediated CD8 T cells, anti-β-cell antibodies, and macrophage activity.

There is. Autoimmunity is an international, peer-reviewed medical journal that covers the pathogenesis, immunology, genetics, and molecular biology of immune and autoimmune responses. In addition, the journal focuses on the autoimmune processes associated with systemic lupus erythematosus, rheumatoid arthritis, Sjögren syndrome, diabetes, multiple sclerosis, and other systemic and Discipline: Immunology.

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Always update books hourly, if not looking, search in the book search column. Enjoy % FREE. The Emerging Role of Neuro-Immune Synapses and the Immunological Homunculus in the Context of the Systematic Lymphoid Organs Innervation.

Evolving concept By Clemens Wülfing, Fenja Amrei Schuran, Inga Hölge, Julia Urban, Jasmin Oehlmann and Hauke Simon Günther Nearly all body tissues are connected to the central nervous system through the axonal.

Purchase The Heart in Systemic Autoimmune Diseases, Volume 14 - 2nd Edition. Print Book & E-Book. ISBN R.G. Landes Company, p. Organ specific autoimmune disorders as a group are responsible for a major portion of all debilitating and at times life threatening chronic diseases.

Over the past decade more has been learned concerning the molecular pathogenesis of these disorders than during. A variety of cellular and molecular responses mediates organ-specific cardiac autoimmunity or participates in the pathogenesis of cardiac-related damage due to systemic conditions, which includes abnormal function of the complement system and its regulatory proteins, pro- and anti-inflammatory cytokine imbalance, and a shift toward T helper 1 Author: Oded Shamriz, Udi Nussinovitch, Noel R.

Rose, Noel R. Rose.A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to his own tissue constituents.

It may be systemic (e.g., systemic lupus erythematosus), or organ specific, (e.g., thyroiditis). Definition (NCI_NCI-GLOSS).Only in very recent times have therapies been developed that are specific to a particular manifestation of autoimmune disease, and these have begun to replace the all-purpose remedies of the past 30 years.

This volume, which draws on the principles of immunology presented in Volume (Autoimmunity: Concepts and Diagnosis at the Cutting Edge), extends these .

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