ring enlargement of certain imidazoline derivatives by Albert William Thews

Cover of: ring enlargement of certain imidazoline derivatives | Albert William Thews

Published .

Written in English

Read online


  • Pyrimidines.,
  • Organic compounds -- Synthesis.

Edition Notes

Book details

Statementby Albert William Thews.
The Physical Object
Pagination18 leaves, bound :
Number of Pages18
ID Numbers
Open LibraryOL14293461M

Download ring enlargement of certain imidazoline derivatives

Graduate Thesis Or Dissertation The ring enlargement of certain imidazoline derivatives Public Deposited. Analytics × Add to Author: Albert William Thews. Download PDF: Sorry, we are unable to provide the full text but you may find it at the following location(s): (external link). Synthesis and characterisation of novel Imidazoline derivatives with potential antidepressant activity Experiment Findings (PDF Available) May with Reads How we measure 'reads'.

content of the imidazoline ring.4–6 GLC, TLC, and HPLC were not suitable for this study, however, because the fatty acid used was a mixture and the product was not easily quantitatively determined by these methods. Furthermore, GLC was not certain to provide ideal analysis results because the amino-amide could be cyclized further into theFile Size: KB.

The Synthesis of Imidazoline Derivative Compounds 43 surface coverage, θ, at various concentrations of compound 1b, 2b and 3b at 27 o C was also presented on Table 4.

Imidazoline derivatives are a novel class of cationic surfactants, with a wide range of applications, mainly used as softeners and antistatic agents in fabrics, and as hair conditioning agents [24]. imidazoline derivatives were carried out by the same experimental methods.

As second step, imidazoline derivatives, which have been synthesized from TETA and NA factions, put into reaction with % acetic acid, leading formation of water soluble complexes. Reaction was carried out both and molar ratios and performedFile Size: KB.

pharmaceuticals and treatment of various diseases. The imidazole ring occurs in a number of naturally occurring compounds, and very widely distributed in essentials amino acids, L-histidine and its derivatives have powerful pharmacological properties.

Purins, present in living systems contain the imidazole Size: KB. NOVAL IMIDAZOLINE DERIVATIVES gasundaram*, kumar, ss, Reddy and Aanandhi.

School of Pharmaceutical Sciences, Vels University, ChennaiTamilnadu, India E-mail:[email protected] ABSTRACT A new series of N substituted methyl 2 - phenyl imidazoline were synthesized from the reaction of phenyl.

Imidazole is an entity which has interesting physical and chemical properties, in the present article focus lies on analysis of these properties which in turn may be exploited for different pharmacological activities, like compounds having a 3,4,5-trimethoxyphenyl ring linked to.

THE RING ENLARGE1'1ENT OF CERTAIN IMIDAZOL1NE DEH1VAT1VES by ALBERT WILLIAM THEWS. THESI. submitted t. o THE RING ENLARGEMENT OF. CER~AI. IMIDAZOLINE S. which has since arisen in derivatives of orotic acid, as.

Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.

When fused to a pyrimidine ring Chemical formula: C₃H₄N₂. Imidazoline is a class of heterocycles formally derived from imidazoles by the reduction of one of the two double bonds. Three isomers are known, 2-imidazolines, 3-imidazolines, and 4-imidazolines. The 2- and 3-imidazolines contain an imine center, whereas the 4-imidazolines contain an alkene group.

The 2-Imidazoline group occurs in several drugs. Imidazoline derivatives, a class of novel cationic surfactants are presently gaining importance in global detergent market due to their wide range of applications.

These are extensively used mainly as fabric softeners and antistatic agents. The present communication reviews the preparation, reaction scheme, reaction rates and properties of Cited by: The imidazoline clonidine has been reported to exert anxiolytic effects in humans in certain situations.

clonidine reduces the anxiety associated with ethanol (Wallinder et al., ), opiate (Gold et al., ; Ginzburg, ) or nicotine (Ornish et al., ) withdrawal. clonidine also has been found to exert anxiolytic effects in patients suffering from panic disorder (Udhe et al., ; Hoehn-Saric et al.

Imidazoline derivatives have been widely used since the s, when naphazoline was launched on the pharmaceutical market. 2,4,11,14 Since then, sporadic works, Table 1 - Brand names, active ingredient and concentration of imidazoline derivates involved in 72 cases of acute exposure in children Brand name Active ingredient Concentration (%) n %.

2-Imidazoline is one of three isomers of the nitrogen-containing heterocycle imidazoline, with the formula C3H6N2. The 2-imidazolines are the most common imidazolines commercially, as the ring exists in some natural products and some pharmaceuticals.

They also have been examined in the context of organic synthesis, coordination chemistry, and homogeneous Number: Chemically amphoteric imidazoline derivatives don’t have imidazoline ring in the molecule but during syn-thesis of such compound, an intermediate imidazoline ring structure formed, hence called imidazoline derivatives of amphoteric imidazolines have both of the charges on molecule and may show the.

The derivatives of imidazoline are known for diverse pharmacological activities and some of them are in clinical use as antiinflammatory, antihypertensive, antitumor, antidiabetic, and antiparasitic agents.

Abstract. The influence of ring strain on certain characteristic vibrational frequencies of carbonyl derivatives of oxazoline and imidazoline is analysed on the basis of experimental results and approximate molecular orbital calculations.

The MO results show that in conjugated cyclic π-electronic systems increased angular strain causes an increase in Cited by: 2.

Imidazole and Benzimidazole Synthesis is a comprehensive survey of the known methods of syntheses and ring modification. It brings together the multitude of synthesis of the imidazole ring in a systemic way interms of specific bond formation, and recommends the most attractive synthetic approaches.

It also collects non-ring-synthetic approaches to classes of compounds such as nitro- halogeno Reviews: 1.

Related imidazole-derived heterocycles. Classified as a diamine, it is formally derived by the addition of four hydrogen atoms to imidazole. The intermediate, resulting from the addition of only two hydrogen atoms is called imidazoline (dihydroimidazole).

The connection of imidazolidine to related compounds is indicated in the Number: History. The Buchner ring expansion reaction was first used in by E. Buchner and T. Curtius who prepared a carbene from ethyl diazoacetate for addition to benzene using both thermal and photochemical pathways in the synthesis of cycloheptatriene derivatives.

The resulting product was a mixture of four isomeric carboxylic ions in the reaction arise from methods of carbene. Imidazoline Derivatives Based on Coffee Oil as CO2 Corrosión Inhibitor Article (PDF Available) in International journal of electrochemical science 10(3) - February with Reads.

1. Nitroxyl radicals in 3-imidazoline 3-oxide are not oxidized by halogens, whereas nitroxyl radicals in 3-imidazoline react with chlorine, bromine, and nitrous acid with fission of the imidazoline ring.

4-Carboxyimidazolineoxyls on treatment with bromine and nitrous acid undergo recyclization to 3-oxazolinones. Bromine treatment of 4-formyl- and 4-acetylimidazolinoxyl Author: G. Shchukin, I. Grigor'ev, L. Volodarskii. Oxadiazoles were used in the realm of excited-state intramolecular proton investigations, which typically result in a large Stokes shift of the emission (JPOC) and enhances the solid-state emission characteristics of certain derivatives (JPCPB(A)51).

Similar to oxazoles, such effects can be observed, when a 2-hydroxyphenyl substituent forms a six-membered ring via an intramolecular H-bond. The Buchner–Curtius–Schlotterbeck reaction is the reaction of aldehydes or ketones with aliphatic diazoalkanes to form homologated ketones.

It was first described by Eduard Buchner and Theodor Curtius in and later by Fritz Schlotterbeck in Two German chemists also preceded Schlotterbeck in discovery of the reaction, Hans von Pechmann in and Viktor Meyer in Abstract. A new reduction ring-opening reaction of 2-imidazoline with sodium borohydride is reported, and the effect of reaction condition on the yield, reaction mechanism and the use of the new reaction in synthesis of ethylenediamine derivatives are by: 3.

acids and their derivatives.6 Biswanath das et al. reported synthesis of 5-substituted 2,3-diphenyl and 5-substituted 1-aryl-2,3-diphenyl imidazoles using polyethylene glycol.7 Cheng-he zhou et al.

prepared a series of ether bis-imidazoles and their derivatives.8 Majid M. Heravi et al. reported acidic ionic liquid {[(CH 2) 4SO 3HMIM][HSO 4]} aFile Size: KB.

A novel imidazoline derivative, 2-methylphenyltosyl-4, 5-dihydro-1H-imidazole (IMI), was prepared and investigated as corrosion inhibitor for P carbon steel in M HCl solution by. J Oleo Sci. ;56(5) Imidazoline and its derivatives: an overview. Tyagi R(1), Tyagi VK, Pandey SK.

Author information: (1)Department of Chemical Engineering, Jaypee Institite of Engineering and Technology, Guna, India. Imidazoline derivatives, a class of novel cationic surfactants are presently gaining importance in global detergent market due to their wide range of by:   In this study, cationic surfactants having different alkyl chain lengths were prepared by amidation of lauric, myristic, palmitic, stearic, oleic acids with diethylene triamine.

The products were quaternized using chloroacetic acid. The chemical structure of the prepared compounds was elucidated using different spectroscopic techniques. The critical micelle concentration (CMC) and the free Cited by: This project is supported by the Canadian Institutes of Health Research (award #), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization.

Aziridines and azirines are the simplest of the heterocyclic ring systems containing nitrogen, containing just two carbon atoms and one nitrogen. Aziridines are the fully saturated example of this heterocyclic ring system, while azirines contain a single double bond. The literature was reviewed for information on imidazoline hydrolysis.

Conflicts involving structures and mechanisms of hydrolysis have been found. Researchers also disagree as to the role of water and whether a protonated form of the imidazoline exists. However, there is agreement that the rate of hydrolysis is dependent on pH and by: Abstract. 1 ST, 2-(2,6-diethylphenylamino)imidazoline hydrochloride produces in animal experiments bradycardia, and in larger doses, also hypertension, due to α-sympathomimetic activity and probable central sympathetic inhibition.

2 The effects of ST, after oral administration, were studied in 10 healthy volunteers. A dose-dependent, significant decrease of the heart rate was by: 3. The reaction of alkyl halides with 2-(arylimino)imidazolidines (I) leads to imidazoline derivatives II, in which the side chain is situated at the bridge nitrogen atom between the phenyl group and the imidazoline ring.

The new imidazolines (II) exert a specific bradycardic action at a cardiac by: Full text Full text is available as a scanned copy of the original print version.

Get a printable copy (PDF file) of the complete article (K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected by: 2. S. Baluja and N.

Kacchadia, "Physicochemical Study of some Imidazoline Derivatives in Solutions", International Letters of Chemistry, Physics and. INTRODUCTION.

Coumarin (1,2-Benzopyrone or 2Hbenzopyranone, or phenylpropanoids, 1) and its derivatives (coumarins) are widely distributed throughout nature and many exhibit useful and diverse biological activities [1, 2].Coumarins occur as secondary metabolites in the seeds, roots and leaves of many plant species, notably in high concentration in the tonka bean and thus the name Cited by:.

The Structure of Certain Simple Imidazole Derivatives. Ring Enlargements. I. The Ring Enlargement of 2-Chlorocyclohexanone and 2-Phenylcyclohexanone. C. David. Gutsche; Journal of the American Chemical SocietyJournal of the American Chemical Society imidazole [im″id-az´ōl] 1.

an organic compound in which two of the five atoms that make up the ring are nitrogen atoms. It is an antimetabolite and inhibitor of histamine and is used as an insecticide. 2. any of a class of antifungal agents that contain this compound. imidazole (im-id'ă-zōl), A five-membered heterocyclic compound occurring.Current methods for asymmetric α-arylation require blocking groups to prevent reaction at the α′-carbon, basic conditions that promote racemization, or multistep synthesis.

This work records the first catalytic enantioselective examples of the diazoalkane-carbonyl homologation reaction. Medium ring 2-aryl ketones are prepared in one step in up to er and 99% yield from the Cited by:

51978 views Tuesday, November 10, 2020